>>I don't believe anyone would say there won't be a case of PML somewhere. However - the label, which puts the potential at 1:1000 is high. If it were accurate, there would be about 30 cases of PML by now instead of zero.
It is still a bit early to tell how big an issue PML will be. I too think 1:1000 will prove high. But I would also bet that in time we will see PML in MS patients on T alone. I take some comfort in the T Risk Management Plan. My single point of contact with T-RMP shows they take the plan very seriously.
I do think the ability to clear the system of T, should that be advisable, in just one day will encourage the neuros to treat with T.
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There are times when rules and precedents cannot be broken; others when they cannot be adhered to with safety. (Thomas Joplin)