Here's a slightly different look at those recent buyouts to large premiums that you listed.
I've added the premium relative to it's 52 week high, short interest (% of float), at it's 52w high and SI when it was bought out.
The changes in short interest doesn't seem to be indicative of anything either way, but the premium relative to it's 52w high certainly shows that buy & hold is not the path to riches.