<b> Insider Transactions Since 2006 ATryn Approval in EU </b> [Includes transactions through 3/14/08. Please see <a href='read_msg.asp?message_id=28839364'>#msg-28839364</a> for current insider holdings.] PURCHASES <b><u>Geoffrey Cox, CEO</u></b> 14-Mar-2008 93,000 shares @$0.45-0.50 13-Dec-2007 10,765 shares @$0.88-0.90 13-Aug-2007 14,200 shares @$1.02-1.03 14-Mar-2007 24,000 shares @$0.99-1.01 08-Nov-2006 14,300 shares @$1.05-1.07 === Total (5 purchases): 153,265 shares @$0.45-1.07 <b><u>Jack Green, CFO</u></b> 14-Dec-2007 1,500 shares @$0.89 <u><b>Harry Meade, SVP Research</b></u> 14-Dec-2007 10,000 shares @$0.90 <u><b>Greg Liposky, SVP Oprtns</b></u> 17-Dec-2007 1,100 shares @$0.87 <u><b>Daniel Woloshen, Gen. Counsel</b></u> 17-Dec-2007 1,200 shares @$0.89 <u><b>James Geraghty, Director</b></u> 14-Dec-2007 10,000 shares @$0.87 <u><b>Mary Ann Gray, Director</b></u> 17-Dec-2007 10,000 shares @$0.88 SALES <u><b>Daniel Woloshen, Gen. Counsel</b></u> 12-Mar-2008 17,000 shares @$0.57 22-Dec-2006 7,500 shares @$1.10 <u><b>Greg Liposky, SVP Oprtns</b></u> 12-Mar-2008 22,900 shares @$0.56-0.57 SEC links: <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866208000112/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866208000112/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000400/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000400/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000291/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000291/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000131/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000131/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000118095506000107/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000118095506000107/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000406/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000406/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000407/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000407/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000409/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000409/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000411/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000411/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000435/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000435/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866207000413/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866207000413/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866208000109/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866208000109/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866206000415/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866206000415/xslF345X02/edgar.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/904973/000090866208000110/xslF345X02/edgar.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000090866208000110/xslF345X02/edgar.xml</a>