AI
Wednesday, April 30, 2008 1:03:14 AM
MNTA: This ENBREL? Not terribly complex, imo. Any crack lab worth it's salt could whip this up. There are only 7,054 atoms comprising the molecule:
C2224 H3475 N621 O698 S36
Experimental/off-label uses
Given the central role of TNF-alpha in many diseases, etanercept is being studied as treatment for a number of these disease, including over 150 clinical trials.[8] This includes certain forms of vasculitis (such as Wegener's granulomatosis, in which it was not effective).[9]
A 2006 pilot study showed small but significant improvements in various cognitive rating scales in patients with Alzheimer's disease after treatment with etanercept.[10] A further study, administering to a single AD patient via perispinal infusion, showed rapid and significant improvement in Alzheimer's symptoms.[11]
http://en.wikipedia.org/wiki/Etanercept
January 15, 2008
Enbrel Works Fast Against Alzheimer's Disease?
Injected near the spine Enbrel delivers very rapid results.
A drug commonly used to treat arthritis caused a dramatic and rapid improvement in patients with Alzheimer's disease, according to physicians in California. However, scientists and others not involved in the work worry that the report, which was based on trials in a few patients and hasn't been independently confirmed, may offer little more than false hope for Alzheimer's sufferers and their families.
Alzheimer's patients injected with the anti-inflammatory drug etanercept--marketed as Enbrel--showed dramatic improvements in their functioning within minutes, according to Edward Tobinick, director of the Institute for Neurological Research, a private medical facility in Los Angeles where the patients were treated, and an assistant clinical professor of medicine at the University of California, Los Angeles.
"The patients improve literally before your eyes," says Tobinick, who began using etanercept in Alzheimer's patients three years ago. He uses an unconventional method to administer the drug; he injects it near patients' spines.
Will affluent Alzheimer's sufferers seek out doctors capable of delivering this treatment? Will it spread even without big clinical trials to check its effectiveness? Think about it. If you had early stage Alzheimer's would you try something like this? I would.
Suppose this turns out to work really well. If the relief from this treatment is long lasting then the methods under development to detect beta amyloid plaque years before disease diagnosis will end up getting used in routine screenings of people in their 40s and 50s. One way or another early detection will get used to trigger the use of preventive treatments against Alzheimer's once such treatments become available.
http://www.futurepundit.com/archives/004930.html
C2224 H3475 N621 O698 S36
Experimental/off-label uses
Given the central role of TNF-alpha in many diseases, etanercept is being studied as treatment for a number of these disease, including over 150 clinical trials.[8] This includes certain forms of vasculitis (such as Wegener's granulomatosis, in which it was not effective).[9]
A 2006 pilot study showed small but significant improvements in various cognitive rating scales in patients with Alzheimer's disease after treatment with etanercept.[10] A further study, administering to a single AD patient via perispinal infusion, showed rapid and significant improvement in Alzheimer's symptoms.[11]
http://en.wikipedia.org/wiki/Etanercept
January 15, 2008
Enbrel Works Fast Against Alzheimer's Disease?
Injected near the spine Enbrel delivers very rapid results.
A drug commonly used to treat arthritis caused a dramatic and rapid improvement in patients with Alzheimer's disease, according to physicians in California. However, scientists and others not involved in the work worry that the report, which was based on trials in a few patients and hasn't been independently confirmed, may offer little more than false hope for Alzheimer's sufferers and their families.
Alzheimer's patients injected with the anti-inflammatory drug etanercept--marketed as Enbrel--showed dramatic improvements in their functioning within minutes, according to Edward Tobinick, director of the Institute for Neurological Research, a private medical facility in Los Angeles where the patients were treated, and an assistant clinical professor of medicine at the University of California, Los Angeles.
"The patients improve literally before your eyes," says Tobinick, who began using etanercept in Alzheimer's patients three years ago. He uses an unconventional method to administer the drug; he injects it near patients' spines.
Will affluent Alzheimer's sufferers seek out doctors capable of delivering this treatment? Will it spread even without big clinical trials to check its effectiveness? Think about it. If you had early stage Alzheimer's would you try something like this? I would.
Suppose this turns out to work really well. If the relief from this treatment is long lasting then the methods under development to detect beta amyloid plaque years before disease diagnosis will end up getting used in routine screenings of people in their 40s and 50s. One way or another early detection will get used to trigger the use of preventive treatments against Alzheimer's once such treatments become available.
http://www.futurepundit.com/archives/004930.html
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