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Re: iwfal post# 5628

Friday, 04/11/2008 1:15:28 PM

Friday, April 11, 2008 1:15:28 PM

Post# of 12660
>What is the precise definition of PSB?<

For the purposes of our discussion (phase-3 vs phase-2 results in drug programs), the definition is as follows:

Program-survival bias is the difference between:

a) the aggregate results observed in phase-3 trials actually conducted; and

b) the aggregate results that would have been observed in phase-3 trials if every program were allowed to advance from phase-2 to phase-3 regardless of the observed results in phase-2.

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