"Your silly speculations are just that , silly." Possibly true, but what "non-silly" speculations do you have about Entremed that keep you invested? For some reason, silly or not, I still think the science is sound even though clinical results (Panzem) have been a disappointment (at least to Wall Street). Part of the disappointment(s) I believe were inevitable due to trial protocols. If I were to criticise management it would be for waiting so long to implement RA Panzem trials. Once approved for RA, a lot of doors would have opened.....and still will. Am I frustrated as an investor? Damn Right! But I don't know of a better VC play than this one. If I did, I'd put my money where my mouth was and stop posting here. JMHO Ken