GTC Biotherapeutics (fka GTCB)

[RufusT]

Not sure if this is in the "Read Me First" but it's another Wiedermann article, it's in english, it's free, very complete and I sure as Hell hope this is the way antithrombin really works:

Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis
http://ccforum.com/content/10/1/209
This review assembles the available experimental and clinical data on biological mechanisms of antithrombin in inflammatory coagulation activation. Preclinical research has demonstrated partial interference of heparin – administered even at low doses – with the therapeutic effects of antithrombin, and has confirmed – at the level of cellular mechanisms – a regulatory role for antithrombin in DIC. Against this biological background, re-analyses of data from randomized controlled trials of antithrombin in sepsis suggest that antithrombin has the potential to be developed further as a therapeutic agent in the treatment of DIC. Even though there is a lack of studies employing satisfactory methodology, the results of investigations conducted thus far into the mechanisms of action of antithrombin allow one to infer that there is biological plausibility in the value of this agent.