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Re: DewDiligence post# 60402

Sunday, 03/16/2008 10:06:59 PM

Sunday, March 16, 2008 10:06:59 PM

Post# of 257257
>>The latter, IMO.

The Avastin label in metastatic colorectal cancer, which includes use with all varieties of infusional-5FU chemotherapy, is a good precedent.
<<

Thanks. I was thinking the former, i.e. that it would require a telaprevir/Albuferon trial to obtain FDA approval for that combination.

5FU has many years of experience behind it. I presume that there is very little difference between the different "varieties" of 5FU. It is not so clear that the *new* drug Albuferon would combine with the *new* drug telaprevir the same way that Pegasys combines with telaprevir ... as determined by a Phase 3 clinical trial.

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