Dew, Dr. Cox made mention of a letter in Nature re inflamatory nature of DIC, is this referenced in the RMF section? Also I thought your questions were great. Can you speculate on the following: one of the authors of the letter (or article) was from Scripps the other from J and J I believe. Interesting that this info should be dropped during the call. One wonders what the impact of recognition of the importance of AT III by a J and J scientist (if I did not misunderstand) might have on J and J being acutely aware of this product and in active negotiations. Now that would be a good thing. bp