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exwannabe

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exwannabe

Re: docbanker post# 3441

Monday, 02/25/2008 5:48:54 PM

Monday, February 25, 2008 5:48:54 PM

Post# of 8473
"iii) the bar is 1/2 what was seen in prior studies (where the effect was retroactively studied)"

That is simply not true. The "bar" is or course the P value.

The statement that the trial is 85% powered based on 1/2 the prior effect is missing a really important point. Namely, there has to be a std dev (or such) assumption in there. Given that nobody I know of has references to actuall data from the P1/2s (just summary), we have no clue on what this is the earlier trials.

I guess if clark want'd to waste some time he could he could make a much better comment on this.

BTW, what is a "registrational quality" trial?

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