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Re: palindromy post# 2397

Tuesday, 02/12/2008 8:05:18 PM

Tuesday, February 12, 2008 8:05:18 PM

Post# of 3757
>I find it surprising that the company started with a high dose [of IDX899] and is going lower, I thought it was more typical to start off with the lower doses.<

Dose escalation was done in the phase-1 multi-dose study in healthy volunteers in order to ascertain the PK and a maximum tolerated dose. This paved the way for the existing phase-1/2 study to test a dose of 800mg.

On today’s webcast, JP offered a surprising reason for testing doses of 100, 200, and 400mg per day in the next study. The reason is intriguing and hence I’m making it a quiz smile

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