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Re: DewDiligence post# 57820

Tuesday, 01/22/2008 8:41:16 AM

Tuesday, January 22, 2008 8:41:16 AM

Post# of 257250
Dew - Earlier this week I said I would be trying to understand the coagulation pathways, but now having done some research it looks very much like it is not a well understood system. We may know many of the component players in the pathways, but we don't really understand all the feedback loops nor why, in aggregate, the system works the way it does - e.g. Factor V Leiden polymorphism appears to have a significant effect on excess clotting in veins, but not in arteries. But no real idea why.

Do you have best site (or book) that explains such things as which factors play the most important role in different situations or which drugs in which situations and why?

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