>as to the short duration, the protocol in the published study is 4 days of infusion and the Leo study is 5 days -- is one extra day likely to be that important?<
Probably not. What is more consequential than the number of days of treatment is whether a trial’s protocol allows for antithrombin dose adjustment based on a patient’s antithrombin level during treatment. Leo’s trial presumably permits such adjustment.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”