>Does anyone realistically expect the HD trial to fail?<
Failure to show non-inferior efficacy is unlikely for the reasons mentioned in #msg-25866013.
However, the trial could conceivably fail because: i) There are serious protocol violations; or ii) Some bizarre side effect shows up in a single patient in the ATryn arm.
All told, success is likely, IMO, but it cannot be taken for granted.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”