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Re: DewDiligence post# 1421

Tuesday, 03/09/2004 7:39:37 AM

Tuesday, March 09, 2004 7:39:37 AM

Post# of 257295
I am very interested in REGN's VEGF trap, not just for ocular disease but oncologic indications as well. And, yes, we will see just how quickly this trial enrolls, I also believe REGN could be a potential competitive threat to GENR. Where is our Phase II enrollment? Dr. Levitt needs to get CRACKING!!!! Aventis is clearly exhibiting signs of agressiveness.

Regarding Ludwig and GENR. I didn't view that PR as a signal there was potential for problems with the MEDI collaboration. I think MEDI is having some common 'issues' with the FDA, and internal administrative obstacles to overcome; i.e. FDA requesting more preclinical data, perhaps they need further manufacturing validation on the compound, maybe a new trial design has been suggested, perhaps there has been a delay/mishap in aligning the principle investigators, schedules have moved out, clinical trial site has changed.

My first thought from the PR yesterday, was a comment Dr. Levitt made regarding Roche awhile back or was it Takaeda were looking for IL-9 components and they were waiting on the IP position to strengthen before they licensed. My supposition is this two year extension with Ludwig may be associated with pharma and GENR researching something in the early preclinical stage, in vivo/vitro synergy.


Now slap that knee! smile

katie...



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