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Re: masterlongevity post# 199

Sunday, 12/23/2007 1:00:53 PM

Sunday, December 23, 2007 1:00:53 PM

Post# of 890
Schedule:

By the way I saw your estimate on the BV board:


AAB001- estimate 15 months enrollment + 18 month duration= 33m
==> Sept 2010 for final data
estimate interim after 9 months = Dec 2009



There is no guidance on enrollment, but I expect it will be far faster than you suggest. Unfortunately there is a limiting-step - the parallel EU trials.

One thing that I believe I know is because the "symptomatic" endopoint is usually measured at 6 months, then I would expect that is when the interim look might be.

Therefore I would expect:


aab001 - NA trials (by Elan)
=> estimate 4 months enrollment + 18 month duration = 22m
=> Oct 2009 for final data (if they open the data-box)
=> estimate interim @ 6 months = Oct 2008 (but awaits EU)



aab001 - EU trials (by Wyeth)
=> estimate start Feb '08
=> estimate 6 months enrollment + 18 month duration = 24m
=> Feb 2010 for final data
=> estimate interim after 6 months = Feb 2009




"....on the biotech battle-field, you need some élan...."

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