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Re: DewDiligence post# 54325

Monday, 11/05/2007 3:31:02 PM

Monday, November 05, 2007 3:31:02 PM

Post# of 257665
Torcetrapib’s fatal flaw was evidently
not what it was thought to be.


I've seen speculation that it was:

a) Blood pressure related (and therefore unique to Torc)

b) RLT related (and therefore class related)



Now there is a possibility it is aldosterone related. Maybe. I'd want to see the paper. I still think that based upon epidemiological data there is a good bet this is class related. The epidemiological story for LDL is very clean (lower is better) - the epidemiological story for CETP is much much muddier.

Clark

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