Just for your information, but Pharming already received an orphan designation more than a year ago. It also has been given fast track from the FDA for acute HAE. <a href="http://www.pharming.com/index.php?act=show&pg=304&hl=orphan" target="_blank">http://www.pharming.com/index.php?act=show&pg=304&hl=orphan</a> It is only in the prophylactic indication that LEV might be the first: