RespireRx Pharmaceuticals Inc (fka RSPI)

[enemem]

>>RD and analgesia. The fact that opioid receptors can influence respiratory function 'downstream' does not mean it has to be a two-way street. The receptors CX717 hits for RD are not opioid receptors, and the animal studies showed no effect on analgesia. We can't be sure that is the same in humans yet, but downstream interventions do not necessarily affect upstream processes.

I didn't mean to imply that ampakines work on opioid receptors. Neurons involved in espiratory rhythm generation express opioid receptors, and their depression is a direct (not downstream) effect of opioid administration. They also express AMPA receptors, which is why this depression is reversed by ampakines.
Afferent pathways (at least with respect to these two receptor types) are analogous. So if ampakines rescue respiration, I don't see why they wouldn't also reduce analgesia.