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Re: DewDiligence post# 4715

Monday, 08/20/2007 7:43:52 PM

Monday, August 20, 2007 7:43:52 PM

Post# of 19309
O.K., without using Ketamine as an example, if GTC's cheaper version of Factor VIIa could be used in heroic life-saving settings such as blood substitutes have, I imagine the various militaries would give audience and "establish" a pathway.
Whether a "biologic" or traditional "drug" is mere verbage when heroic life-saving is concerned.
When considering the body of research available, this is viable IF LFB/GTC can provide quantities en masse cheaply.

"About 50% of combat deaths are due to fatal bleeding. The aim of this analysis was to assess the efficacy and safety of recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk A/S, Bagsvaerd, Denmark) when used to treat trauma-related blood loss."

"RESULTS: Haemostatic efficacy was achieved in 43/45 (95.6%) patients following rFVIIa administration, and transfusion requirements (defined as median units of packed red blood cells administered in the 24-hour period following rFVIIa administration) were reduced from 10 to 3 units (P < 0.001). Coagulation status also showed improvement (median values for activated partial thromboplastin time and prothrombin time decreased from 43 to 37 s [P < 0.001] and from 19 to 12 s [P = 0.026], respectively). No safety concerns were raised by the available data."






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