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Re: rancherho post# 4721

Monday, 08/20/2007 3:10:28 AM

Monday, August 20, 2007 3:10:28 AM

Post# of 12660
The MS in TAX327 for asymptomatic pts was 23.0 months. Even if the MS for the GVAX arm is 30.7 months, there is still a 20% chance it won't be stat sig superior to Tax. VITAL-1 was powered and designed at a time when CEGE believed the MS target to beat was 18.9 months. In addition, all of the Phase 2 pts were at Johns Hopkins, and got excellent supportive care. I don't think the same will occur at the other trial centers. Lastly, I don't think allogenic cancer immunotherapeutics work. None have worked yet in any randomized trial. So we'll see.

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