GTC Biotherapeutics (fka GTCB)

[anotherbiotechguy]

Including an artficial intron before a cdna sequence is not the same as expressing from genomic DNA. I'll tell you for a fact that the GTC epo/albumin fusion contains no introns within the coding region of the final product. All of their constructs contain the necessary upstream and downstream elements for efficient expression. As for your broad reaching generalization about cDNA constructs... I'll leave you to think what you will.