> As far as I can tell, Gabapentin ER matches or exceeds Lyrica’s half-life, but Lyrica has a more linear PK and a better therapeutic index. <
A study I looked at last winter (from Canada) pegged pregabalin more cost-effective than gabapentin (not sure if they used generic gabapentin). The depo dose is 1800 mg (given once or twice daily depending on the trial arm). If the pain reduction results are good but do not stack up against pregabalin (the latter has more pain free days in prior trials) then how would it fare in the marketplace? They will have a benefit of only dosing at 1800 and not going to 2400 or 3600 (so no dose AEs). Thoughts?