>>Archemix and Merck KGaA Sign Strategic Alliance Jun 11 2007, 7:00 AM EST
Business Wire
Archemix Corp. and Merck Serono, a division of Merck KGaA, Darmstadt, Germany, announced today that they have formed a multi-year strategic alliance to discover, develop and commercialize first-in-class aptamer therapeutics with a primary focus on the treatment of cancer. The alliance combines Archemix' proprietary SELEX technology to discover and generate aptamer candidates with Merck's demonstrated oncology drug development and commercialization capabilities.
Under the terms of the agreement, Archemix will receive a $29.8 million equity investment from Merck KGaA. Merck KGaA also retains an option, under certain circumstances, to acquire additional Archemix common stock upon an initial public offering. Other financial terms were not disclosed. This is the second research agreement this year between the two companies.
The collaboration gives Merck Serono the option to obtain product licenses to certain of Archemix's lead stage aptamer programs in oncology and the right to select and develop aptamers against six additional targets in oncology and other indications, including autoimmune and inflammation disorders. In addition, Merck Serono is granted a license to use Archemix's SELEX(R) technology for internal target validation. Archemix has the option to exercise a co-development and co-promote option on any of the products being developed on a 50:50 cost and profit-sharing basis in the United States.
"The collaboration with Merck Serono represents a key strategic initiative for Archemix and the development of our pipeline, especially in the area of cancer," said Errol De Souza, Ph.D., President and CEO, Archemix. "We will be working with a recognized leader in drug development to discover, develop and commercialize first-in-class aptamer-based therapeutics. With our co-development and co-promote options we can participate in the development and commercialization of certain of the products that come out of the collaboration while simultaneously generating cash flows to fund our proprietary aptamer pipeline."
"Aptamers have the potential to play a key role in the next generation of drugs in our core therapeutic areas," said Dr. Bernhard Kirschbaum, Executive Senior Vice President and Director of Research, Merck Serono. "Archemix is the leader in the discovery of aptamer therapeutics and we believe that, as a class, aptamers can create a new paradigm of treatment."
About Aptamers
Aptamers are single-stranded nucleic acids that form well-defined three dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to antibodies. Aptamers combine the optimal characteristics of small molecules and antibodies, including high specificity and affinity, chemical stability, low immunogenicity and the ability to target protein-protein interactions. In contrast to monoclonal antibodies, aptamers are chemically synthesized rather than biologically expressed.
About Archemix
Archemix Corp. is a privately-held biopharmaceutical company developing aptamers as a class of directed therapeutics for the prevention and treatment of human disease. The company is leveraging its proprietary drug discovery technology to fuel the growth of its development portfolio, which is primarily focused on acute cardiovascular and hematology diseases and cancer. Archemix's broad product pipeline, being developed both by the company as well as its licensees, includes multiple investigational compounds at various stages of development, several of which are moving into Phase II clinical trials. Archemix's lead proprietary product, ARC1779, a selective platelet inhibitor, is anticipated to start Phase IIa clinical trials before the end of 2007. Archemix' leadership position in intellectual property, technology and expertise relating to aptamers has enabled it to form numerous collaborations with biotechnology and pharmaceutical collaborators, including Merck Serono, Pfizer Inc., Elan Pharma, Nuvelo, Inc., Antisoma plc., and Regado Biosciences. For more information, please visit www.archemix.com.
About Merck
Merck KGaA is a global pharmaceutical and chemical company with sales of EUR 6.3 billion in 2006, a history that began in 1668, and a future shaped by 35,091 employees in 62 countries. Its success is characterized by innovations from entrepreneurial employees. Merck's operating activities come under the umbrella of Merck KGaA, in which the Merck family holds an approximately 70% interest and free shareholders own the remaining approximately 30%. In 1917 the U.S. subsidiary Merck & Co. was expropriated and has been an independent company ever since.<<
>>Archemix and Takeda to Enter into Collaboration for Discovery and Development of Aptamer Therapeutics Jun 11 2007, 7:00 AM EST
Business Wire
Archemix Corp. ("Archemix") and Takeda Pharmaceutical Company Limited ("Takeda") announced today that both parties have signed a multi-year, three target agreement that focuses on the discovery, development and commercialization of first-in-class aptamer-based therapeutics.
Under the agreement, Archemix will receive an upfront payment of $6 million from Takeda to discover and generate product candidates to three disease-associated targets identified by Takeda, and Takeda will be granted exclusive, worldwide rights for research, development, manufacturing and commercialization for any resulting aptamer-based products. Archemix will also receive committed research funding and research and clinical development milestone payments for each target selected for therapeutic development. In addition, Archemix will earn royalties and milestones on worldwide sales of the developed aptamers commercialized by Takeda. Detailed financial terms were not disclosed.
"Our alliance with Takeda is the sixth major partnership we have formed within the past year and is a major step in the continued validation of aptamer therapeutics," said Errol De Souza, Ph.D., President and CEO, Archemix. "Takeda is an excellent partner for Archemix and this collaboration is a key component of successfully implementing our strategy of forming collaborations with multi-national pharmaceutical companies to rapidly advance aptamer programs into clinical development."
"We are very impressed with Archemix' track record of success in creating therapeutic aptamers," said Dr. Shigenori Ohkawa, General Manager of Pharmaceutical Research Division, Takeda. "Archemix is the leader in the discovery of aptamer therapeutics and we believe that, as a class, aptamers have the potential to create a new paradigm of treatments in a broad spectrum of diseases, and we believe this collaboration will surely contribute to enhancing our R&D pipeline as source for future growth of Takeda."<<
This technology has been around awhile but seems to now be gathering steam. SELEX stands for "Systematic Evolution of Ligands by Exponential Enrichment." At one time a companion technology to evolve peptide ligands was called SPERT (Systematic Polypeptide Evolution by Reverse Translation). The name may have done it in.
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