Scientific Rationale for Atryn in DIC/Sepsis (This is the detailed version.)
“Treatment Effects of High-Dose Antithrombin Without Concomitant Heparin in Patients With Severe Sepsis With/Without Disseminated Intravascular Coagulation” Kienast, J et al J Thromb Haemost. 2006 Jan;4(1):90-7 Abstract: #msg-9313165. Paper: http://ihub.bedida.net/Key_DIC_sepsis_article.pdf
“Benefit/Risk Profile of High-Dose Antithrombin in Patients with Severe Sepsis Treated With and Without Concomitant Heparin” Hoffmann, J et al Thromb Haemost. 2006 May;95(5):850-6. Abstract: #msg-10993909.
“Antithrombin for Severe Sepsis? Try Again But Without the Heparin!” Jilma, B Thromb Haemost. 2006 May;95(5):755. Editorial: #msg-20139747.
“High-Dose Antithrombin in the Treatment of Severe Sepsis in Patients with a High Risk of Death: Efficacy and Safety” Wiedermann, CJ Crit Care. 2006 Feb 34(2):285-92.
“Recombinant Human Antithrombin Inhibits Thrombin Formation and Interleukin-6 Release in Human Endotoxemia” Leitner, JM et al Clin Pharmacol Ther. 2006 Jan;79(1):23-34. Abstract: #msg-9313029.
“Endogenous Anticoagulant Therapy for Sepsis: Success and Failure” Wiedermann, CJ Internist (Berl). 2007 Mar 28; Abstract: #msg-18336592
“New Aspects in Management of Disseminated Intravascular Coagulation: DIC and Antithrombin” Uchiba, M Japanese J of Intensive Care Med, 25:11 843-848 (2001); #msg-19983732.
Preclinical support
“Efficacy of Antithrombin in the Prevention of Microvascular Thrombosis During Endotoxemia” Sorg, H et al Thromb Res. 2007 May 17; Abstract: #msg-19868753.
“Treatment Effects of Antithrombin on Coagulation Abnormalities in Rats With Endotoxaemia” Qiao, YJ et al Abstract: #msg-18166129
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.