Re: Interim Look Strategy
I like this. There is a real chance that whatever alpha is allocated to the interim will be wasted, reducing the value of the final reading.
The real benefit of the interim may be its effect on negotiations. If it's supportive (let's hope strongly supportive) the FDA has to fear that a further wait of two years could finally produce some hostile scrutiny. And as you say it will send a signal to the various players who are able to provide financing, via partnership, acquisition, or lending. So it makes sense to play it your way, saving the alpha for the final look, while using the interim to affect the psychological game.