>If the interaction study turns out well, he loses because it reminds everyone what a boob he was not to include triple-therapy studies in the plan from the beginning.<
JP has nothing to be ashamed of. Running phase-2 trials without riba was a calculated gamble taken with the full support of NVS. If a company isn’t willing to take a calculated gamble, it shouldn’t be in the drug business.
As goseek said, the companies did not expect the severity of the GI problems that occurred at the 800mg dose. Had phase-2 been able to continue with the 800mg dose, riba might not have been needed and we probably wouldn’t be having this conversation.
“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”