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Sunday, 04/29/2007 7:06:53 PM

Sunday, April 29, 2007 7:06:53 PM

Post# of 20689
Largest Shareholders as of Apr 15, 2007

[List excludes mutual funds such as Fidelity whose holding consists of accounts for individual customers. The % ownership includes options exercisable now or within 60 days of 4/15/07, the cut-off date in the annual-meeting proxy.]

http://www.sec.gov/Archives/edgar/data/1235010/000110465907032586/a07-6436_1def14a.htm

Novartis 13.0%
Ziff Asset Management 8.3%
OrbiMed 7.5%
Atlas/Peter Barrett 6.9%
Palo Alto Investors 6.1%
Polaris 5.0%
MVM Int’l Life Sciences/Stephen Reeders 3.9%
Robert Langer, Jr. 2.8%
Alan Crane 1.7%
CHP II, L.P/John Clarke 1.7%
Ganesh Venkataraman 1.5%
Ram Sasisekharan 1.4%

All directors/officers, including affiliates: 22.0%

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”