Largest Shareholders as of Apr 15, 2007 [List excludes mutual funds such as Fidelity whose holding consists of accounts for individual customers. The % ownership includes options exercisable now or within 60 days of 4/15/07, the cut-off date in the annual-meeting proxy.] <A HREF="http://www.sec.gov/Archives/edgar/data/1235010/000110465907032586/a07-6436_1def14a.htm" target="_blank">http://www.sec.gov/Archives/edgar/data/1235010/000110465907032586/a07-6436_1def14a.htm</A> Novartis 13.0% Ziff Asset Management 8.3% OrbiMed 7.5% Atlas/Peter Barrett 6.9% Palo Alto Investors 6.1% Polaris 5.0% MVM Int’l Life Sciences/Stephen Reeders 3.9% Robert Langer, Jr. 2.8% Alan Crane 1.7% CHP II, L.P/John Clarke 1.7% Ganesh Venkataraman 1.5% Ram Sasisekharan 1.4% All directors/officers, including affiliates: 22.0%