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Re: poorgradstudent post# 44900

Friday, 04/13/2007 4:56:45 PM

Friday, April 13, 2007 4:56:45 PM

Post# of 257453
>> The absence of the intended immune response in the Provenge group suggests that, if anything, the placebo group has a chance to benefit from the procedure rather than being disadvantaged. <<

This is something I'm not quite clear on. Is the placebo infusion treated identically to Provenge , except for the addition of fusion antigen , or is it simply stored and reinfused ?

The APC-enrichment steps that are done prior to antigen incubation could be the MOA of Provenge , for all they know , so if the placebo prep does not get this treatment that is indeed a serious flaw in the trial design.

Anybody know , offhand ?

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