Biotech Values

[dewophile]

"Response for HCV is due to the virus' sensitivity to the drug"

but it is also due to the concentration of drug at target sites...the obvious example would be more efficient GI absorption and increased bioavailability of the drug..another could be due to improved target organ absorption from circulation, or increased binding in tissues, regardless of whether that tissue is the liver (which would translate to efficacy) or another tissue like the skin (rash)..another possibility is synergy with another agent in the cocktail - DD speculated some time ago that the rash may in fact be due to boosting of ribavirin, as rash is a common SE of ribavirin..who knows, but certainly it is at least plausible that efficacy and side effects could be linked