Biotech Values

[jessellivermore]

With all due respect to your opinion...ie that shortened telemeres are not the primary defect in Progeria. The fact is these individuals are born with telemeres the length of 70 to 80 year olds. IMHO this is the primary problem. The fact some other problem involving DNA synthesis or repair has caused this shortening is understandable and expected. The fact that something causes the shortening in no way trivialises the importance of telemer length.

I think we both agree on the importance of DNA "change" in aging. I guess the word "primary" is the problem. If "primary" means "the first or the earliest" then I see your point; If "primary" means most sigifcant, then IMHO it is the short telemeres.