I followed Maxygen for several years before giving up on them. They started with a great technology and some great scientists. But megalomaniac CEO Howard really trashed the company, in too many ways to mention here. Almost all the good scientists left over the years (some of whom I have talked to) and the only reason the company hasn't totally crashed is because the raised a lot of money in their IPO and by selling off parts of the business, and also because the technology was good enough to generate a few interesting molecules. But I wouldn't invest in any company with Howard as CEO. He talks the talk, but doesn't walk the walk.