Why RECIST can favor TKI-like responses 1) Size-based measurement RECIST 1.1 mainly measures change in lesion diameter. TKIs often cause: quick shrinkage of driver-dependent lesions noticeable radiographic responses within weeks That translates directly into: partial responses (PR) higher ORR Slow immune remodeling is undercounted Therapies like: Pembrolizumab cell therapy some antibody combinations may produce: delayed responses stable disease first pseudoprogression uneven lesion responses RECIST can undervalue these patterns.
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