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Re: Hoskuld post# 2317

Tuesday, 03/17/2026 1:48:37 PM

Tuesday, March 17, 2026 1:48:37 PM

Post# of 2356
If the SLS trial gets populated quickly - yes - we should have some readout data for efficacy and likely sometime before 2027, or at minimum during Q1 of 2027.

GPS - that one is more interesting. We know there were 72 of 80 'events' in the trial as of December of last year. The CEO is also using terms like 'curative' or 'functional cure' for a very deadly form of blood cancer in LinkedIn posts. There were only 12 additional events (to result in the 72 figure) over about a year before that in the GPS trial. Assuming (and it is only an assumption) that additional 'events' since December are continuing to accumulate at about 1 per month, we 'might' have 75-76 events as of mid March.

But what if GPS is really 'curative' for at least a subset of patients who have a really good and sustained immune response, and the death rate for patients remaining in the trial really has dropped to a rate approximating those dying from natural causes? At some point - it would seem to me that the Independent Review Group eventually has to open the data back up and halt the trial for overwhelming success?

Just - what is that point going to be?

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