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Re: iwfal post# 257078

Wednesday, 02/18/2026 7:12:25 PM

Wednesday, February 18, 2026 7:12:25 PM

Post# of 257426

OCUL—…there were clearly a large number of more minor safety issues compared to eylea. Probably mostly related to having a high dose of a TKI (much broader activity than VEGF mab), so potentially getting worse on redosing…

Moreover, absent a vitretomy, the TKI elution cannot be stopped if there’s a more serious safety problem.

Based on currently available information this is not a treatment I would want for myself or a family member. Regrettably, I do have a family history of wet AMD.

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