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Re: DewDiligence post# 256901

Thursday, 02/05/2026 7:57:00 PM

Thursday, February 05, 2026 7:57:00 PM

Post# of 257473
Re: PFE ‘3944 for obesity

PFE didn’t disclose the raw (not placebo-adjusted) weight loss in the phase-2b trial of ‘3944, leading some people to infer that the placebo arm experienced modest weight gain. The CSO said on PFE’s CC that the placebo arm was “stable, not really up or down,” but this is consistent (IMO) with a placebo-arm gain of, say, 2%, which would make the placebo-adjusted weight-loss numbers somewhat less impressive.

We’ll know the details at ADA in June.

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