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NY1972

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NY1972

Re: jondoeuk post# 892

Monday, 12/29/2025 10:26:44 PM

Monday, December 29, 2025 10:26:44 PM

Post# of 971
ChatGPT top pick
Metastatic CRC (post-FOLFOX/FOLFIRI ± carbotaxol)
Why #1
Strong taxane-induced MICA/B upregulation
High ADAM10/17-mediated shedding
EGFR rebound common after chemotherapy
PD-1 largely ineffective (MSS majority)
Net effect
CAR-T bypasses shedding
Cetuximab regains potency after CAR-T debulking
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