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Re: DewDiligence post# 2866

Saturday, 03/03/2007 2:58:14 AM

Saturday, March 03, 2007 2:58:14 AM

Post# of 19309
what I really like about this deal is that one of the big advantages of GTC and Pharmings technology are well read here.

While the utility of human plasma derived butyrylcholinesterase (hBChE) to protect against nerve agent toxicity is well documented, a major limitation hindering its commercial development has been the inability to produce commercial quantities of hBChE due to a limited availability of appropriate blood supplies, low levels of the protein in plasma, and low production yields using traditional biotechnology methods. PharmAthene's recombinant hBChE overcomes these limitations by enabling substantially larger production yields than are possible using other expression systems or through purification of the native protein from human plasma. Transgenic production and manufacturing is estimated to be capable of supplying sufficient rBChE to make Protexia® available for use by the military and civilian populations.

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