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Re: DewDiligence post# 42539

Tuesday, 02/27/2007 6:10:12 PM

Tuesday, February 27, 2007 6:10:12 PM

Post# of 257253
HGSI Albuferon addendum:

The non-inferiority threshold in the two phase-3 trials is 6% (12% if calculated as two-sided). The trials are powered at 90% to achieve non-inferiority vs Pegasys for at least one of the two Albuferon doses.

The power for showing superiority of at least one dose of Albuferon to Pegasys is closer to 80%.

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