Dew. re " Its a clown show " post you have highlighted above . Care to explain why you would high light such a post ? The poster has no idea of the risk reduction seen in NVO's CKD trial that was stopped for efficacy . But IMHO its no small thing to stop a major trial at interim for efficacy so its unlikely to be a clown show for those with CKD heading towards ESRD You probably have some idea of what % of trials are stopped this way . Kiwi