Innovation Pharmaceuticals Inc (IPIX)

[frenchbroad]

For you. Stop crying.
"Thanks to the use of several different methods, the researchers concluded that combining brilacidin with either of two antifungals (caspofungin or voriconazole) could kill resistant strains of several fungal species that cause infections in humans, such as Aspergillus fumigatus, which causes invasive pulmonary aspergillosis.
In addition to the combinations with antifungals for lung infections, brilacidin alone blocked growth of A. fumigatus and development of the disease in an animal model of fungal keratitis, an infection of the cornea that affects 1 million-2 million people per year worldwide, especially in tropical countries with intense agricultural activity, as it frequently results from corneal abrasion by plant debris. In the United States and other developed countries, wearing contact lenses contaminated by fungi is the main risk factor.
Another advantage of brilacidin detected by the researchers was that its combination with caspofungin or voriconazole acted against different species of fungus. In tests involving an animal model, the caspofungin-brilacidin combination was effective against other species besides A. fumigatus, such as Candida albicans, Candida auris and Cryptococcus neoformans.
"Caspofungin doesn't kill A. furmigatus but hinders its multiplication. This is often sufficient for the host's immune system to control the infection, but not always, so it's important to identify drugs that can act in synergy with caspofungin. One option would be to develop a single medication combining caspofungin and brilacidin so that they acted together."
Gustavo Henrique Goldman, last author of the article and professor at FCFRP-USP
This potential application of the drug has been patented....."
https://www.news-medical.net/news/20230710/New-drug-shows-synergistic-effect-with-antifungals-in-killing-drug-resistant-fungi.aspx