Aptose Biosciences Inc (APTO)

[dcaf7]

Tried to refresh my memory on Lux G3 and noticed something weird. Look at slide 31 of EHA presentation. It shows time course of Lux plasma concentration in cycle 1 at different drug doses. First, Look at 900 mg dose curve. Lux level reaches almost 1 uM on day 15 and then it drops to ~0.15 uM at the end of cycle. Second, how to explain a sudden plunge in plasma Lux on day 15 with 750 mg G1 and 50 mg G3? And why so many measurements on day 15? Third, why to compare 50 mg G3 with 900 mg G1, a worst PK dose, and not with 600 mg G1? Fourth, why do you see plasma Lux decline with 50 mg G3 from day 8 to day 15 and day 22? Where is data for day 29?