Tornado Alley (PROG)

[fuagf]

Magaverse: Male. Female. That's it. It's like the good old days of black and white. The world changes. Science changes. We don't. Our certainty is our strength. Black, white, brown, brindle. Too much complication. Male female. Black white. We aren't fish:

Abstract

Sexual fate is no longer seen as an irreversible deterministic switch set during early embryonic development but as an ongoing battle for primacy between male and female developmental trajectories. That sexual fate is not final and must be actively maintained via continuous suppression of the opposing sexual network creates the potential for flexibility into adulthood. In many fishes, sexuality is not only extremely plastic, but sex change is a usual and adaptive part of the life cycle. Sequential hermaphrodites begin life as one sex, changing sometime later to the other, and include species capable of protandrous (male-to-female), protogynous (female-to-male), or serial (bidirectional) sex change. Natural sex change involves coordinated transformations across multiple biological systems, including behavioural, anatomical, neuroendocrine, and molecular axes. We here review the biological processes underlying this amazing transformation, focussing particularly on its molecular basis, which remains poorly understood, but where new genomic technologies are significantly advancing our understanding of how sex change is initiated and progressed at the molecular level. Knowledge of how a usually committed developmental process remains plastic in sequentially hermaphroditic fishes is relevant to understanding the evolution and functioning of sexual developmental systems in vertebrates generally, as well as pathologies of sexual development in humans.

https://karger.com/sxd/article/10/5-6/223/296444/Bending-Genders-The-Biology-of-Natural-Sex-Change

Imagine an artist painting with only primary colors.

Medicine’s Fixation on the Sex Binary Harms Intersex People | A Question of Sex, Episode 2

Scientific American

12,736 views Aug 24, 2022
“Normalizing” infants’ and children’s genital appearance to match a sex assigned in early age isn’t medically necessary and can negatively impact quality of life.
https://www.youtube.com/watch?v=GFIugrTaSmM

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Pediatric Ambiguous Genitalia

Ambiguous genitalia is a rare condition in which an infant’s external genitals don't appear to be clearly male or female. The genitals may not be well-formed or the baby may have characteristics of both sexes. And, the infant’s external sex organs may not match his or her internal sex organs or genetic sex.
https://www.childrens.com/specialties-services/conditions/ambiguous-genitalia