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jondoeuk

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jondoeuk

Re: NY1972 post# 58

Tuesday, 06/20/2023 1:51:21 PM

Tuesday, June 20, 2023 1:51:21 PM

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AUTO4 has a unique targeting mechanism. Mature T-cells express either T-cell receptor B-chain constant domains 1 or 2 (TRBC1 or TRBC2). T-cell lymphomas are clonal and either express TRBC1 or TRBC2. So a targeting strategy based on mutually exclusive expression of TRBC domains can spare a proportion of the normal T-cell compartment.
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