Biotech Values

[gofishmarko]

>> Expansion of indications for Cell-Cept <<

Have they looked at use as an antiviral ? VRTX had an IMPDH inhibitor in development for HCV but has stopped work on it - not sure why. I know it had some activity in combo with ifn/riba and the following abstract suggests similar activity in HIV.

(free full-text available)
http://tinyurl.com/23b3vm

"In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1."


The new HCV antivirals might provide a niche for some previously discarded drug candidates , as part of novel combo txs.