Inovio Pharmaceuticals Inc (INO)

[doc2016]

killer tcell 37%.

biomarker is the question. what is the problem/
biomarker used is associated with hpv created immunologic interfering agent? figure out what is being blocked and add it's treatment. ? pdl1 or such?

regeneron and inovio?
Vaccines for human papilloma virus and methods for using the same
Patent number: 10905755
Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
Type: Grant
Filed: March 11, 2019
Date of Patent: February 2, 2021
Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
Inventors: David Weiner, Jian Yan
PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
Patent number: 10835595
Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
Type: Grant
Filed: January 6, 2015
Date of Patent: November 17, 2020
Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai