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Re: DewDiligence post# 237575

Friday, 02/10/2023 3:35:14 PM

Friday, February 10, 2023 3:35:14 PM

Post# of 257470
BMY/TVST report Abecma data from phase-3 KarMMa-3 study:

https://www.businesswire.com/news/home/20230209005647/en

At a median follow up of 18.6 months, treatment with Abecma (n=254) demonstrated a clinically meaningful and statistically significant improvement in the primary endpoint of progression-free survival (PFS) compared with standard regimens (n=132), with a median PFS of 13.3 months (95% CI: 11.8-16.1) vs. 4.4 months (95% CI: 3.4-5.9), respectively (HR:0.49; p<0.0001).

Abecnma is currently FDA-approved for fifth-line MM; the results above should enable a label expansion into the third-line setting.

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