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Re: DewDiligence post# 245400

Wednesday, 02/08/2023 9:36:42 AM

Wednesday, February 08, 2023 9:36:42 AM

Post# of 257661

Bayer’s competition in this arena (Factor XI, XIa) is BMY/JNJ’s Milvexian



FWIW the leader is Anthos Therapeutics, a private company, with Abelacimab. The whole saga is interesting because I tried to invest almost a decade ago, but Ionis is a disaster of mismanagement (see note below on Ionis). And a disaster for patients because for a LONG time the experts derided the whole concept of immensely lower bleeding risk for some important classes of clot prevention.

https://www.prnewswire.com/news-releases/abelacimab-first-factor-xi-inhibitor-to-enroll-patients-in-a-phase-3-clinical-trial-301541160.html

Regarding Ionis: recently heard former Ionis CEO Stanley Crooke on a podcast and he was surprisingly forthright. He intentionally torched any attempts to make product revenue because he strongly believes it destroys science.

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