Party continues today.. Dudley added, “Additionally, as we have previously indicated, we received written authorization from FDA allowing us to proceed with our Phase 0 first-in-human (FIH) clinical trial with our lead candidate, TTX-MC138, in cancer patients with advanced solid tumors. We intend to proceed with patient enrollment as soon as possible.” TTX-MC138 targets microRNA-10b, believed to drive metastatic disease. TTX-MC138 has been validated preclinically in multiple cancer models including metastatic breast cancer and pancreatic cancer and has previously been shown to induce durable regression of metastatic disease in murine models of disseminated breast cancer and pan…..
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