Revive Therapeutics Ltd (RVVTF)

[Ecomike]

Just got a chance to look at this (downloaded the article).

https://www.reddit.com/r/RVVTF/comments/101z7y6/targeting_sarscov2_by_synthetic_dualacting_thiol/
Posted by u/_nicktendo_64

Here is the article:

https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202201157RR

Right off the bat it clearly says NAC and Bucillamine are gangbuster ways to fight the Covid crud and other viruses..

"The environmental redox state is an important factor for
enveloped viruses' life cycle. The thiol–disulfide balance
plays an important role in receptor recognition by the
SARS-CoV-2 spike (S) protein. Given that a correct protein
conformation is required for protein function and that disulfide bonds are often crucial both for structural stability and conformational changes, it is not surprising that
the reduction of the disulfides into sulfhydryl groups in
the receptor binding domain (RBD) seriously impairs the
binding to ACE2.

1,2 Thus, manipulation of the redox status of the cysteine-rich glycoproteins in the virus envelope can influence viral cell entry.

Cleavage of disulfide bonds by thiol-reducing compounds can efficiently weaken viral binding and prevent SARS-CoV-2 infection"